Beilstein J. Org. Chem.2016,12, 2351–2357, doi:10.3762/bjoc.12.228
approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography.
Keywords: environmentalfactor; flash chromatography; green metrics; mass intensity; purification; Introduction
As part of a more respectful environmental
on the environmentalfactor E of a process seems pretty obvious, we have developed here a tool to quantify it. In an extremely favourable case with a 95% pure sample (x = 0.95), a very easy separation achievable with a small mass of silica (A = 10) and Rf = 0.35, we find, for low density eluent (0.6
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Graphical Abstract
Figure 1:
Chromatographic peak of a compound eluted at a retention volume VR with a width ω.
Beilstein J. Org. Chem.2006,2, No. 3, doi:10.1186/1860-5397-2-3
use of this parameter is to adapt reaction sequences in a way that transformations with low atom economy are limited to a minimum.
Environmentalfactor (E-factor) [5][6][7][8]
This factor is the ratio of the weight of generated waste to the total weight of the end product. It is a useful tool for
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Graphical Abstract
Scheme 1:
Reduction of nitrobenzene to aniline [23]